The Visionary - Spring 2015 - page 4

T
T
ime is an amazing thing.
When we are older or up
against a deadline time
seems to accelerate. It seems
like just yesterday that I
came to LEITR although
it was in September 2013.
When you and your
Team are working to set up a
new program at LEITR, time
also seems to slip by faster
than you thought possible.
However, I am pleased to
say that the Ocular
Research Center Team has
made significant progress
towards our short and
long term goals..
First, the new equipment for
processing tissue is being
used daily.
The two research projects,
one using ultrasound to image
donor tissue for possible
disease conditions and a second
examining possible links with
a donor’s positive sputum
cultures and the suitability of
their corneas for transplantation,
were accepted and successfully
presented at
the ARVO
2014 meeting.
In addition, three more research
projects were submitted for
consideration for ARVO 2015
(May 2015) and all three have
been accepted for presentation.
We have also made progress
on supplying our research
clients with tissue that has been
dissected and processed here
at LEITR in order to better
preserve the tissue.
The Team has also succeeded
in setting up various research
models including growing
ocular cells in culture and an
exciting glaucoma model system.
I would like to spend the rest
of this column on describing
the glaucoma model system
that explores the biology of the
trabecular meshwork (TM).
The trabecular meshwork is a
filter that is composed of interlaced
beams covered with cells responsible
for filtering aqueous humor (a liquid
produced by the eye to supply
nutrients to the front [anterior]
parts of the eye) prior to it exiting
the eye through Schlemm’s Canal.
You may have heard of the TM and
aqueous humor if you or a loved one
has glaucoma.The termglaucoma is
a single word that actually describes
a spectrumof glaucoma diseases that
can lead to death of retinal ganglion
cells and the subsequent loss of
vision that starts at the periphery
of the retina. A common type of
glaucoma, POAG (primary open
angle glaucoma), is characterized
with increased intraocular pressure
and is treated with drugs to reduce
the production of aqueous humor or
with surgery to increase the outflow.
LEITR
Research
Breakthroughs you've
helpmake happen.
4 | Lions Eye Institute Newsletter
Ashley Morganti, lead scientist for the
POC model, places the dishes into a CO2
incubator. The anterior portion of the eye
mounted in the dishes is bathed in cell culture
media (red colored liquid visible in the dish)
which is deliveredby theplastic tubingattached
to the dish. The incubator keeps the tissue at
human body temperature in an atmosphere
of 95% air and 5% CO2 which has been
shown to promote healthy cells when they
are maintained outside of the body.
Mitchell D. McCartney, Ph.D.
1,2,3 5,6,7,8,9,10,11,12
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